Cardarine, or GW501516, has been recently gaining some popularity. It is wrongly labelled as a SARM (Selective Androgen Receptor Modulator), it in facts acts on PPAR receptors activating the same genes that activates whenever we perform any physical activity. It is therefore more correct to label cardarine a SPPARM.
Cardarine has found therefore a valuable position among PEDs (performance enhancement drugs), to the point of being added to the blacklist of WADA in 2009. Despite being originally created to treat obesity and diabetes, its research has been slowed down and interrupted and some point when some studies showed up some correlation between its use and cancer on rats, defining it a potential carcinogenic substance.
This should not be something to be panicked for. The time frames of its used on this studies were not the same used for performance enhancing or aesthetic purposes on humans. Besides, some studies have actually shown how cardarine can have an opposite effect on some types of cancer, showing signs of regression on those.
It definitely showed great effects on LDL\HDL ratio, improving it and anti-inflammatory effects on tissues aiding the repair and recovery.
Cardarine, just like any other SARM, is not strictly regulated and it is sold like any other supplement on the internet. If this is good on one side, as it’s very easy to find, it’s bad on another, as there are no measures that actually control and guarantee that what you’re buying is authentic cardarine and in that exact amount. It is therefore recommended to read feedbacks on the internet regarding to the different brands that commercialise this product and hope that what you’re getting is that much cardarine.
Its uses on performances and aesthetic pruposes
Cardarine has been largely used to improve cardiovascular performances, therefore being very suitable for sports that have a main aerobic component. Having said that, you may wonder what’s the advantage on someone who’s pumping iron at the gym? First, cardarine improves recovery times, allowing longer and more intense training sessions, indirectly contributing to mass and strength gains.
As demonstrated, cardarine can also shift the body energetic consumption in favour of fats, allowing therefore a greater lipolysis and fat loss, and it does not do it like any other stimulant, as it doesn’t not act on beta or beta adrenergic receptors like ephedrine or clenbuterol.
In bodybuilding it can be used anywhere, during bulking cycles to limit fat gain as well as in cutting cycles as a fat burning aid. It’s definitely a good product for a body recomposition and a great aid to help on cholesterol levels during a cycle.
Recommended dosages are 15-20mg to be taken on a full stomach, for a period of 8-12 weeks (this is not intended to be taken as a medical adivce, but it’s a simple report of the dosages utilised on bodybuilders and users around and on studies)
Geiger LE et al. Rat carcinogenicity study with GW501516, a PPAR delta agonist (2009)
Péchery A et al. Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells. 2016 Tumor Biol.
Li Xi et al. Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model. 2015 Int J Mol Med
Guo J et al. Peroxisome proliferator-activated receptor δ improves porcine blastocyst hatching via the regulation of fatty acid oxidation. 2017 Theriogenology.
Ooi EM et al. Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity. 2011 J Endocrinol Metab.